1639300-84-7

1639300-84-7 structure

1639300-84-7 structure

Name: Sulfo-ara-F-NMN
Chemical Name: Sulfo-ara-F-NMN
CAS Number: 1639300-84-7
Molecular Formula: C₁₁H₁₅FN₂O₆PS
Molecular Weight: 353.28
Create Date: 2019-12-08 22:05:32
Modify Date: 2024-01-31 19:02:56
Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production[1].

Name	Sulfo-ara-F-NMN

Description	Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production[1].
In Vitro	Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death[1].
References	[1]. Zhao ZY, et al. A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death. iScience. 2019 May 31;15:452-466.

Molecular Formula	C₁₁H₁₅FN₂O₆PS
Molecular Weight	353.28