102704-40-5
102704-40-5 structure
- Name: GAT-211
- Chemical Name: GAT211
- CAS Number: 102704-40-5
- Molecular Formula: C22H18N2O2
- Molecular Weight: 342.391
- Catalog: Signaling Pathways GPCR/G Protein Cannabinoid Receptor
- Create Date: 2020-01-13 13:39:01
- Modify Date: 2023-01-18 22:05:37
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GAT-211 (GAT211) is a selective cannabinoid 1 receptor (CB1R) positive allosteric modulator with pKb of 7.26, Arrestin2 EC50 of 775 nM; engages CB1R allosteric site(s), enhances the binding of the orthosteric full agonist [3H]CP55,490, and reduces the binding of the orthosteric antagonist/inverse agonist [3H]SR141716A; displayed both PAM and agonist activity in HEK293A and Neuro2a cells expressing human recombinant CB1R (hCB1R) and in mouse-brain membranes rich in native CB1R.
| Name | GAT211 |
|---|---|
| Synonyms |
MFCD02165420
1H-Indole, 3-(2-nitro-1-phenylethyl)-2-phenyl- GAT211 3-(2-Nitro-1-phenylethyl)-2-phenyl-1H-indole |
| Description | GAT-211 (GAT211) is a selective cannabinoid 1 receptor (CB1R) positive allosteric modulator with pKb of 7.26, Arrestin2 EC50 of 775 nM; engages CB1R allosteric site(s), enhances the binding of the orthosteric full agonist [3H]CP55,490, and reduces the binding of the orthosteric antagonist/inverse agonist [3H]SR141716A; displayed both PAM and agonist activity in HEK293A and Neuro2a cells expressing human recombinant CB1R (hCB1R) and in mouse-brain membranes rich in native CB1R. |
|---|---|
| References | References 1. Laprairie RB, et al. ACS Chem Neurosci. 2017 Jun 21;8(6):1188-1203. View Related Products by Target Cannabinoid Receptor |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 585.8±50.0 °C at 760 mmHg |
| Molecular Formula | C22H18N2O2 |
| Molecular Weight | 342.391 |
| Flash Point | 308.1±30.1 °C |
| Exact Mass | 342.136841 |
| LogP | 6.23 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.668 |