1177798-88-7
1177798-88-7 structure
- Name: BRACO 19 trihydrochloride
- Chemical Name: BRACO-19
- CAS Number: 1177798-88-7
- Molecular Formula: C35H46Cl3N7O2
- Molecular Weight: 703.144
- Catalog: Signaling Pathways Anti-infection CMV
- Create Date: 2020-01-12 11:08:51
- Modify Date: 2024-01-02 23:53:48
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BRACO-19 is a potent small molecule Telomerase inhibitor (IC50=115 nM) that inhibits expression of human telomerase reverse transcriptase (hTERT); induces cellular senescence and inhibits growth of uterine cancer cells in vitro, inhibits growth of uterine tumor xenografts in vivo.
| Name | BRACO-19 |
|---|---|
| Synonyms |
N,N'-(9-{[4-(Dimethylamino)phenyl]amino}-3,6-acridinediyl)bis[3-(1-pyrrolidinyl)propanamide] trihydrochloride
1-Pyrrolidinepropanamide, N,N'-[9-[[4-(dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-, hydrochloride (1:3) BRACO-19 N,N'-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) hydrochloride BRACO19 hydrochloride MFCD23380200 |
| Description | BRACO-19 is a potent small molecule Telomerase inhibitor (IC50=115 nM) that inhibits expression of human telomerase reverse transcriptase (hTERT); induces cellular senescence and inhibits growth of uterine cancer cells in vitro, inhibits growth of uterine tumor xenografts in vivo. |
|---|---|
| References | References 1. Gowan SM, et al. Mol Pharmacol. 2002 May;61(5):1154-62. 2. Burger AM, et al. Cancer Res. 2005 Feb 15;65(4):1489-96. 3. Incles CM, et al. Mol Pharmacol. 2003 Nov;64(5):1101-8. 4. Gunaratnam M, et al. Biochem Pharmacol. 2009 Jul 15;78(2):115-22. View Related Products by Target Telomerase |
| Molecular Formula | C35H46Cl3N7O2 |
|---|---|
| Molecular Weight | 703.144 |
| Exact Mass | 701.277832 |
| Hazard Codes | Xi |
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