1202269-24-6
1202269-24-6 structure
- Name: Imarikiren hydrochloride
- Chemical Name: N-Isobutyl-1-(4-methoxybutyl)-N-[(3S,5R)-5-(4-morpholinylcarbonyl)-3-piperidinyl]-1H-benzimidazole-2-carboxamide hydrochloride (1:1)
- CAS Number: 1202269-24-6
- Molecular Formula: C27H42ClN5O4
- Molecular Weight: 536.107
- Create Date: 2020-01-19 20:05:56
- Modify Date: 2025-09-17 22:50:12
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A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay; displays excellent selectivity against other aspartic proteases, such as pepsin and cathepsin D (IC50>10 uM); exhibits a dramatically improved PK profile in rats, and long-lasting antihypertensive efficacy in vivo. Diabetes Phase 2 Clinical
| Name | N-Isobutyl-1-(4-methoxybutyl)-N-[(3S,5R)-5-(4-morpholinylcarbonyl)-3-piperidinyl]-1H-benzimidazole-2-carboxamide hydrochloride (1:1) |
|---|---|
| Synonyms |
N-Isobutyl-1-(4-methoxybutyl)-N-[(3S,5R)-5-(4-morpholinylcarbonyl)-3-piperidinyl]-1H-benzimidazole-2-carboxamide hydrochloride (1:1)
1H-Benzimidazole-2-carboxamide, 1-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(4-morpholinylcarbonyl)-3-piperidinyl]-, hydrochloride (1:1) |
| Description | A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay; displays excellent selectivity against other aspartic proteases, such as pepsin and cathepsin D (IC50>10 uM); exhibits a dramatically improved PK profile in rats, and long-lasting antihypertensive efficacy in vivo. Diabetes Phase 2 Clinical |
|---|---|
| References | References 1. Imaeda Y, et al. ACS Med Chem Lett. 2016 Sep 12;7(10):933-938. View Related Products by Target Renin Diabetes |
| Molecular Formula | C27H42ClN5O4 |
|---|---|
| Molecular Weight | 536.107 |
| Exact Mass | 535.292542 |