Imarikiren hydrochloride
Modify Date: 2025-09-17 22:50:12
Imarikiren hydrochloride structure
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Common Name | Imarikiren hydrochloride | ||
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| CAS Number | 1202269-24-6 | Molecular Weight | 536.107 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H42ClN5O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Imarikiren hydrochlorideA highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay; displays excellent selectivity against other aspartic proteases, such as pepsin and cathepsin D (IC50>10 uM); exhibits a dramatically improved PK profile in rats, and long-lasting antihypertensive efficacy in vivo. Diabetes Phase 2 Clinical |
| Name | N-Isobutyl-1-(4-methoxybutyl)-N-[(3S,5R)-5-(4-morpholinylcarbonyl)-3-piperidinyl]-1H-benzimidazole-2-carboxamide hydrochloride (1:1) |
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| Synonym | More Synonyms |
| Description | A highly potent, selective, orally active renin inhibitor with IC50 of 2.1 nM in hPRA assay; displays excellent selectivity against other aspartic proteases, such as pepsin and cathepsin D (IC50>10 uM); exhibits a dramatically improved PK profile in rats, and long-lasting antihypertensive efficacy in vivo. Diabetes Phase 2 Clinical |
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| References | References 1. Imaeda Y, et al. ACS Med Chem Lett. 2016 Sep 12;7(10):933-938. View Related Products by Target Renin Diabetes |
| Molecular Formula | C27H42ClN5O4 |
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| Molecular Weight | 536.107 |
| Exact Mass | 535.292542 |
| N-Isobutyl-1-(4-methoxybutyl)-N-[(3S,5R)-5-(4-morpholinylcarbonyl)-3-piperidinyl]-1H-benzimidazole-2-carboxamide hydrochloride (1:1) |
| 1H-Benzimidazole-2-carboxamide, 1-(4-methoxybutyl)-N-(2-methylpropyl)-N-[(3S,5R)-5-(4-morpholinylcarbonyl)-3-piperidinyl]-, hydrochloride (1:1) |