1279829-64-9
1279829-64-9 structure
- Name: SAR 216471 hydrochloride
- Chemical Name: N-[6-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)-3-pyridazinyl]-5-chloro-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride (1:1)
- CAS Number: 1279829-64-9
- Molecular Formula: C28H31ClN8O3.HCl
- Molecular Weight: 599.511
- Create Date: 2020-01-20 19:18:56
- Modify Date: 2024-02-04 18:47:16
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SAR-216471 is a potent, highly selective, intravenous and oral, reversible P2Y12 receptor antagonist with binding IC50 of 17 nM; inhibits ADP-induced platelet aggregation in human platelet rich plasma with IC50 of 0.1 uM; exhibits an ED50 of 2.75mg/kg in ex vivo platelet aggregation model in rats.
| Name | N-[6-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)-3-pyridazinyl]-5-chloro-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride (1:1) |
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| Synonyms |
1H-Indole-3-carboxamide, 5-chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-, hydrochloride (1:1)
N-[6-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)-3-pyridazinyl]-5-chloro-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride (1:1) |
| Description | SAR-216471 is a potent, highly selective, intravenous and oral, reversible P2Y12 receptor antagonist with binding IC50 of 17 nM; inhibits ADP-induced platelet aggregation in human platelet rich plasma with IC50 of 0.1 uM; exhibits an ED50 of 2.75mg/kg in ex vivo platelet aggregation model in rats. |
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| References | References 1. Boldron C, et al. J Med Chem. 2014 Sep 11;57(17):7293-316. 2. Delesque-Touchard N, et al. Thromb Res. 2014 Sep;134(3):693-703. View Related Products by Target P2Y Receptor |
| Molecular Formula | C28H31ClN8O3.HCl |
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| Molecular Weight | 599.511 |
| Exact Mass | 598.197449 |