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  • DC Chemicals Limited
  • China
  • Product Name: AT-IAP
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1403898-55-4

1403898-55-4 structure
1403898-55-4 structure
  • Name: AT-IAP
  • Chemical Name: 1-[6-(4-Fluorobenzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-{[(3R)-3-methyl-4-morpholinyl]methyl}-1-piperazinyl]ethanone
  • CAS Number: 1403898-55-4
  • Molecular Formula: C29H40FN5O2
  • Molecular Weight: 509.659
  • Catalog: Signaling Pathways Apoptosis IAP
  • Create Date: 2020-01-11 17:53:50
  • Modify Date: 2024-04-04 18:05:56
  • A potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively; exhibits MDA-MB-231 cell proliferation inhibition with IC50 of 4.4 nM; decreases basal and TNF-α-induced cIAP-1 expression in CaP cells, switches TNF-α signaling from pro-survival to pro-apoptotic and increases radiation sensitivity of CaP cells in co-culture with THP-1 cells; shows in vivo efficacy in Balb/c scid mice bearing MDA-MB-231 xenografts.

Name 1-[6-(4-Fluorobenzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-{[(3R)-3-methyl-4-morpholinyl]methyl}-1-piperazinyl]ethanone
Synonyms Ethanone, 1-[6-[(4-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-[[(3R)-3-methyl-4-morpholinyl]methyl]-1-piperazinyl]-
1-[6-(4-Fluorobenzyl)-3,3-dimethyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridin-1-yl]-2-[(2R,5R)-5-methyl-2-{[(3R)-3-methyl-4-morpholinyl]methyl}-1-piperazinyl]ethanone
Description A potent, orally bioavailable, dual XIAP/cIAP1 inhibitor with EC50 of 5.1/0.32 nM, respectively; exhibits MDA-MB-231 cell proliferation inhibition with IC50 of 4.4 nM; decreases basal and TNF-α-induced cIAP-1 expression in CaP cells, switches TNF-α signaling from pro-survival to pro-apoptotic and increases radiation sensitivity of CaP cells in co-culture with THP-1 cells; shows in vivo efficacy in Balb/c scid mice bearing MDA-MB-231 xenografts.
References References 1. Tamanini E, et al. J Med Chem. 2017 Jun 8;60(11):4611-4625. 2. Armstrong CW, et al. Oncotarget. 2016 Feb 16;7(7):7885-98. View Related Products by Target IAP
Density 1.1±0.1 g/cm3
Boiling Point 678.3±55.0 °C at 760 mmHg
Molecular Formula C29H40FN5O2
Molecular Weight 509.659
Flash Point 364.0±31.5 °C
Exact Mass 509.316589
LogP 4.23
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.549