1404437-50-8

1404437-50-8 structure

Name: BRD 8899
Chemical Name: N-[[(2S,4R)-4-[(4-methyl-5-isoquinolinyl)sulfonylamino]-2-pyrrolidinyl]methyl]acetamide
CAS Number: 1404437-50-8
Molecular Formula: C₁₇H₂₂N₄O₃S
Molecular Weight: 362.447
Catalog: Research Areas Cancer
Create Date: 2020-01-20 16:05:57
Modify Date: 2024-04-05 13:03:59
BRD 8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP); exhibits significant off-target inhibition of a few other kinases, including RIOK1 (97% inhibition), MST4 (96%), RSK4 (89%), ATK1 (85%), KITD816V (85%), ROCK1 (84%), and FLT3 (81%), while STK33 is inhibited by 89%; shows no effect cell viability in 35 cancer cell lines, fails to kill KRAS-dependent cells.

Name	N-[[(2S,4R)-4-[(4-methyl-5-isoquinolinyl)sulfonylamino]-2-pyrrolidinyl]methyl]acetamide
Synonyms	N-[[(2S,4R)-4-[(4-methyl-5-isoquinolinyl)sulfonylamino]-2-pyrrolidinyl]methyl]acetamide Acetamide, N-[[(2S,4R)-4-[[(4-methyl-5-isoquinolinyl)sulfonyl]amino]-2-pyrrolidinyl]methyl]- N-{[(2S,4R)-4-{[(4-Methyl-5-isoquinolinyl)sulfonyl]amino}-2-pyrrolidinyl]methyl}acetamide

Description	BRD 8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP); exhibits significant off-target inhibition of a few other kinases, including RIOK1 (97% inhibition), MST4 (96%), RSK4 (89%), ATK1 (85%), KITD816V (85%), ROCK1 (84%), and FLT3 (81%), while STK33 is inhibited by 89%; shows no effect cell viability in 35 cancer cell lines, fails to kill KRAS-dependent cells.
References	References 1. Luo T, et al. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2860-5. View Related Products by Target Other Targets