BRD 8899
Modify Date: 2024-04-05 13:03:59
BRD 8899 structure
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Common Name | BRD 8899 | ||
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| CAS Number | 1404437-50-8 | Molecular Weight | 362.447 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C17H22N4O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRD 8899BRD 8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP); exhibits significant off-target inhibition of a few other kinases, including RIOK1 (97% inhibition), MST4 (96%), RSK4 (89%), ATK1 (85%), KITD816V (85%), ROCK1 (84%), and FLT3 (81%), while STK33 is inhibited by 89%; shows no effect cell viability in 35 cancer cell lines, fails to kill KRAS-dependent cells. |
| Name | N-[[(2S,4R)-4-[(4-methyl-5-isoquinolinyl)sulfonylamino]-2-pyrrolidinyl]methyl]acetamide |
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| Synonym | More Synonyms |
| Description | BRD 8899 is a potent and selective inhibitor of the serine/threonine kinase STK33 with IC50 of 0.11 nM (25 uM ATP); exhibits significant off-target inhibition of a few other kinases, including RIOK1 (97% inhibition), MST4 (96%), RSK4 (89%), ATK1 (85%), KITD816V (85%), ROCK1 (84%), and FLT3 (81%), while STK33 is inhibited by 89%; shows no effect cell viability in 35 cancer cell lines, fails to kill KRAS-dependent cells. |
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| References | References 1. Luo T, et al. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2860-5. View Related Products by Target Other Targets |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C17H22N4O3S |
| Molecular Weight | 362.447 |
| Exact Mass | 362.141266 |
| LogP | -0.22 |
| Index of Refraction | 1.640 |
| N-[[(2S,4R)-4-[(4-methyl-5-isoquinolinyl)sulfonylamino]-2-pyrrolidinyl]methyl]acetamide |
| Acetamide, N-[[(2S,4R)-4-[[(4-methyl-5-isoquinolinyl)sulfonyl]amino]-2-pyrrolidinyl]methyl]- |
| N-{[(2S,4R)-4-{[(4-Methyl-5-isoquinolinyl)sulfonyl]amino}-2-pyrrolidinyl]methyl}acetamide |