1416709-79-9
1416709-79-9 structure
- Name: PR-924
- Chemical Name: PR-924
- CAS Number: 1416709-79-9
- Molecular Formula: C37H38N4O5
- Molecular Weight: 618.721
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-11 17:22:49
- Modify Date: 2024-01-03 14:17:58
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A potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM); shows weak activity toward LMP2 and no detectable activity toward β1, β2, or MECL1.
| Name | PR-924 |
|---|---|
| Synonyms |
ZI5ZER54A9
D-erythro-3-Pentulose, 4,5-anhydro-1,2-dideoxy-4-C-methyl-2-[[N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-L-tryptophyl]amino]-1-phenyl- PR-924 4,5-Anhydro-1,2-dideoxy-4-methyl-2-({N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-L-tryptophyl}amino)-1-phenyl-D-erythro-pent-3-ulose |
| Description | A potent, specific immunoproteasome LMP7 subunit inhibitor with IC50 of 25 nM, >100-fold selectivity over β5c, β1i, β1c, β2i and β2c subunits (IC50>3 uM); shows weak activity toward LMP2 and no detectable activity toward β1, β2, or MECL1. |
|---|---|
| References | References 1. Parlati F, et al. Blood. 2009 Oct 15;114(16):3439-47. 2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209. View Related Products by Target Proteasome |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 969.0±65.0 °C at 760 mmHg |
| Molecular Formula | C37H38N4O5 |
| Molecular Weight | 618.721 |
| Flash Point | 539.8±34.3 °C |
| Exact Mass | 618.284241 |
| LogP | 6.17 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.648 |
| Hazard Codes | Xi |
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