1638644-62-8

1638644-62-8 structure

Name: OD 36 HCl
Chemical Name: 4-Chloro-7,10-dioxa-13,17,18,21-tetraazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene hydrochloride (1:1)
CAS Number: 1638644-62-8
Molecular Formula: C₁₆H₁₅ClN₄O₂
Molecular Weight: 367.230
Catalog: Signaling Pathways Apoptosis RIP kinase
Create Date: 2020-01-11 18:18:32
Modify Date: 2024-01-14 19:45:53
RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2; inhibits both RIPK2 tyrosine autophosphorylation as well as downstream NF-κB and MAPK signaling induced by MDP, downregulates a panel of RIPK2 kinase-dependent genes; reduces cellular infiltration in an in vivo MDP-induced peritonitis model; also shows high affinity for cyclin G-associated kinase (GAK) with Ki of 3.8 nM.

Name	4-Chloro-7,10-dioxa-13,17,18,21-tetraazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene hydrochloride (1:1)
Synonyms	4-Chloro-7,10-dioxa-13,17,18,21-tetraazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene hydrochloride (1:1) 1,16-Etheno-8,4-metheno-13H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine, 6-chloro-10,11,14,15-tetrahydro-, hydrochloride (1:1)

Description	RIPK2 inhibitor OD36 is a potent, specific, ATP-competitive inhibitor of RIPK2 with IC50 of 5.3 nM, inhibits Tyr and Ser/Thr-directed activities of RIPK2; inhibits both RIPK2 tyrosine autophosphorylation as well as downstream NF-κB and MAPK signaling induced by MDP, downregulates a panel of RIPK2 kinase-dependent genes; reduces cellular infiltration in an in vivo MDP-induced peritonitis model; also shows high affinity for cyclin G-associated kinase (GAK) with Ki of 3.8 nM.
References	References 1. Tigno-Aranjuez JT, et al. J Biol Chem. 2014 Oct 24;289(43):29651-64. 2. Asquith CRM, et al. J Med Chem. 2019 Feb 15. doi: 10.1021/acs.jmedchem.8b01213. View Related Products by Target RIP kinase