169799-04-6
169799-04-6 structure
- Name: CGS 27023A
- Chemical Name: N-Hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(3-pyridinylmethyl)-D-valinamide hydrochloride (1:1)
- CAS Number: 169799-04-6
- Molecular Formula: C18H24ClN3O5S
- Molecular Weight: 429.918
- Create Date: 2020-01-11 16:16:50
- Modify Date: 2022-11-22 15:02:32
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CGS 27023A (MMI 270) is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9.
| Name | N-Hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(3-pyridinylmethyl)-D-valinamide hydrochloride (1:1) |
|---|---|
| Synonyms |
N-Hydroxy-N2-[(4-methoxyphenyl)sulfonyl]-N2-(3-pyridinylmethyl)-D-valinamide hydrochloride (1:1)
Butanamide, N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](3-pyridinylmethyl)amino]-3-methyl-, (2R)-, hydrochloride (1:1) |
| Description | CGS 27023A (MMI 270) is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9. |
|---|---|
| In Vitro | CGS 27023A (MMI 270) is a potent, orally active MMP inhibitor with Ki of 8-43 nM for MMP1/2/3/9; shows growth-inhibitory effects in breast carcinoma, prostate, bladder, colon, lung adenocarcinoma, glioblastoma, and ovarian carcinoma cell line;.protects the cartilage proteoglycan matrix in a partial meniscectomy model of osteoarthritis in rabbits.Solid TumorsPhase 2 Discontinued |
| Molecular Formula | C18H24ClN3O5S |
|---|---|
| Molecular Weight | 429.918 |
| Exact Mass | 429.112518 |