2229039-45-4

2229039-45-4 structure

Name: ZL0420
Chemical Name: 6-[(E)-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-2(1H)-quinolinone
CAS Number: 2229039-45-4
Molecular Formula: C₁₆H₁₆N₄O₂
Molecular Weight: 296.324
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2020-01-11 14:54:55
Modify Date: 2024-04-06 13:09:21
ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively; displays selectivity over BRD2, BRD3, and BRDT (BRD2-BD1 and BRD2-BD2, IC50=803 and 1736 nM); disrupts the BRD4 complex with Pol II and histones, inhibits poly(I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.54 and 0.51 uM); blocks Poly(I:C)-induced inflammation and neutrophilia in vivo.

Name	6-[(E)-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-2(1H)-quinolinone
Synonyms	6-[(E)-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-2(1H)-quinolinone 2(1H)-Quinolinone, 6-[(E)-2-(2-amino-4-hydroxy-5-methylphenyl)diazenyl]-3,4-dihydro-

Description	ZL0420 is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively; displays selectivity over BRD2, BRD3, and BRDT (BRD2-BD1 and BRD2-BD2, IC50=803 and 1736 nM); disrupts the BRD4 complex with Pol II and histones, inhibits poly(I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.54 and 0.51 uM); blocks Poly(I:C)-induced inflammation and neutrophilia in vivo.
References	References 1. Tian B, et al. Cell Rep. 2018 Apr 24;23(4):1138-1151. 2. Liu Z, et al. Eur J Med Chem 2018 May 10;151:450-461. View Related Products by Target Bromodomain