304456-62-0
304456-62-0 structure
- Name: BTYNB
- Chemical Name: 2-{(E)-[(5-Bromo-2-thienyl)methylene]amino}benzamide
- CAS Number: 304456-62-0
- Molecular Formula: C12H9BrN2OS
- Molecular Weight: 309.182
- Catalog: Research Areas Cancer
- Create Date: 2020-01-11 10:49:03
- Modify Date: 2024-01-08 10:43:53
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BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA with IC50 of 5 uM; has no effect on binding of PR to flPRE; destabilizes c-Myc mRNA, downregulates β-TrCP1 mRNA and reduces activation of NF-κB; also decreases oncogenic translation regulator eEF2 mRNA levels in cancer cells; potently inhibits proliferation of IMP1-containing ovarian cancer and melanoma cells with no effect in IMP1-negative cells.
| Name | 2-{(E)-[(5-Bromo-2-thienyl)methylene]amino}benzamide |
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| Synonyms |
Benzamide, 2-[[(1E)-(5-bromo-2-thienyl)methylene]amino]-
2-{(E)-[(5-Bromo-2-thienyl)methylene]amino}benzamide 2-{[(E)-(5-bromothiophen-2-yl)methylidene]amino}benzamide MFCD00977636 |
| Description | BTYNB is a potent and selective inhibitor of IMP1 binding to c-Myc mRNA with IC50 of 5 uM; has no effect on binding of PR to flPRE; destabilizes c-Myc mRNA, downregulates β-TrCP1 mRNA and reduces activation of NF-κB; also decreases oncogenic translation regulator eEF2 mRNA levels in cancer cells; potently inhibits proliferation of IMP1-containing ovarian cancer and melanoma cells with no effect in IMP1-negative cells. |
|---|---|
| References | References 1. Mahapatra L, et al. Transl Oncol. 2017 Oct;10(5):818-827. View Related Products by Target c-Myc |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 495.9±40.0 °C at 760 mmHg |
| Molecular Formula | C12H9BrN2OS |
| Molecular Weight | 309.182 |
| Flash Point | 253.7±27.3 °C |
| Exact Mass | 307.961884 |
| LogP | 2.88 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.685 |
| Hazard Codes | Xi |
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