359886-84-3

359886-84-3 structure

Name: Cdk4/6 Inhibitor IV
Chemical Name: CINK4
CAS Number: 359886-84-3
Molecular Formula: C₂₇H₃₂N₆O
Molecular Weight: 456.583
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2020-01-12 13:50:41
Modify Date: 2024-01-02 11:39:25
Cdk4/6 Inhibitor IV is a cell-permeable triaminopyrimidine compound acting as a reversible and ATP-competitive inhibitor of Cdk4/6 (IC50 = 1.5 ��M and 5.6 ��M for Cdk4/D1 and Cdk6/D1, respectively)

Name	CINK4
Synonyms	CINK4 trans-4-({2-[(1-Benzyl-1H-indol-5-yl)amino]-6-(ethylamino)-4-pyrimidinyl}amino)cyclohexanol Cyclohexanol, 4-[[6-(ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-, trans- trans-4-[[6-(ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol CGP 82996 CGP-82996

Description	Cdk4/6 Inhibitor IV is a cell-permeable triaminopyrimidine compound acting as a reversible and ATP-competitive inhibitor of Cdk4/6 (IC50 = 1.5 ��M and 5.6 ��M for Cdk4/D1 and Cdk6/D1, respectively)
In Vitro	Cdk4/6 Inhibitor IV is a cell-permeable triaminopyrimidine compound acting as a reversible and ATP-competitive inhibitor of Cdk4/6 (IC50 = 1.5 ��M and 5.6 ��M for Cdk4/D1 and Cdk6/D1, respectively) with selectivity over Cdk5/p35 (IC50 = 25 ��M), v-abl, c-met, IGF-1R and IR (IC50 > 10 ��M), Cdk2/A, Cdk2/E, Cdk4/D2, Cdk6/D2 (IC50 > 50 ��M) and Cdk1/B (IC50 > 100 ��M). Cdk4/6 Inhibitor IV exhibits blocking of pRb phosphorylation at Ser780 and Ser795, induce cell cycle arrest (G0/G1), and apoptosis in U2OS and MRC-5 cells at 5 - 10 ��M. Further, suppresses tumor growth in Xenograft mouse model (30 mg/kg, i.p.).