Cdk4/6 Inhibitor IV
Modify Date: 2024-01-02 11:39:25
Cdk4/6 Inhibitor IV structure
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Common Name | Cdk4/6 Inhibitor IV | ||
|---|---|---|---|---|
| CAS Number | 359886-84-3 | Molecular Weight | 456.583 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 755.4±70.0 °C at 760 mmHg | |
| Molecular Formula | C27H32N6O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 410.6±35.7 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Cdk4/6 Inhibitor IVCdk4/6 Inhibitor IV is a cell-permeable triaminopyrimidine compound acting as a reversible and ATP-competitive inhibitor of Cdk4/6 (IC50 = 1.5 ��M and 5.6 ��M for Cdk4/D1 and Cdk6/D1, respectively) |
| Name | CINK4 |
|---|---|
| Synonym | More Synonyms |
| Description | Cdk4/6 Inhibitor IV is a cell-permeable triaminopyrimidine compound acting as a reversible and ATP-competitive inhibitor of Cdk4/6 (IC50 = 1.5 ��M and 5.6 ��M for Cdk4/D1 and Cdk6/D1, respectively) |
|---|---|
| In Vitro | Cdk4/6 Inhibitor IV is a cell-permeable triaminopyrimidine compound acting as a reversible and ATP-competitive inhibitor of Cdk4/6 (IC50 = 1.5 ��M and 5.6 ��M for Cdk4/D1 and Cdk6/D1, respectively) with selectivity over Cdk5/p35 (IC50 = 25 ��M), v-abl, c-met, IGF-1R and IR (IC50 > 10 ��M), Cdk2/A, Cdk2/E, Cdk4/D2, Cdk6/D2 (IC50 > 50 ��M) and Cdk1/B (IC50 > 100 ��M). Cdk4/6 Inhibitor IV exhibits blocking of pRb phosphorylation at Ser780 and Ser795, induce cell cycle arrest (G0/G1), and apoptosis in U2OS and MRC-5 cells at 5 - 10 ��M. Further, suppresses tumor growth in Xenograft mouse model (30 mg/kg, i.p.). |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 755.4±70.0 °C at 760 mmHg |
| Molecular Formula | C27H32N6O |
| Molecular Weight | 456.583 |
| Flash Point | 410.6±35.7 °C |
| Exact Mass | 456.263763 |
| LogP | 4.01 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.680 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 + P330 |
| RIDADR | UN 2811 6.1 / PGIII |
| CINK4 |
| trans-4-({2-[(1-Benzyl-1H-indol-5-yl)amino]-6-(ethylamino)-4-pyrimidinyl}amino)cyclohexanol |
| Cyclohexanol, 4-[[6-(ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-, trans- |
| trans-4-[[6-(ethylamino)-2-[[1-(phenylmethyl)-1H-indol-5-yl]amino]-4-pyrimidinyl]amino]-cyclohexanol |
| CGP 82996 |
| CGP-82996 |