365276-12-6

365276-12-6 structure

Name: TAK-070
Chemical Name: TAK-070
CAS Number: 365276-12-6
Molecular Formula: C₂₇H₃₁NO_.HCl_.H₂O
Molecular Weight: 440.017
Create Date: 2020-01-11 16:07:51
Modify Date: 2024-01-20 18:20:31
A selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays; suppresses the secretion of Aβ with minimum effective concentrations (MECs) for Aβ40 and Aβ42 of 100 and 1000 nM respectively in human IMR-32 neuroblastoma cells, also stimulates sAPPα production with MEC of 100 nM, significantly decreases the secreted level of both human Swedish sAPPβ and mouse endogenous sAPPβ, N-terminal counterparts of APP generated by BACE1 cleavage, by ∼16 and ∼19% respectively at 3 uM; ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.

Name	TAK-070
Synonyms	2-[(2R)-6-(4-Biphenylylmethoxy)-1,2,3,4-tetrahydro-2-naphthalenyl]-N,N-dimethylethanamine hydrochloride hydrate EAC604ZY07 2-Naphthaleneethanamine, 6-([1,1'-biphenyl]-4-ylmethoxy)-1,2,3,4-tetrahydro-N,N-dimethyl-, (2R)-, hydrochloride, hydrate (1:1:1) TAK-070

Description	A selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays; suppresses the secretion of Aβ with minimum effective concentrations (MECs) for Aβ40 and Aβ42 of 100 and 1000 nM respectively in human IMR-32 neuroblastoma cells, also stimulates sAPPα production with MEC of 100 nM, significantly decreases the secreted level of both human Swedish sAPPβ and mouse endogenous sAPPβ, N-terminal counterparts of APP generated by BACE1 cleavage, by ∼16 and ∼19% respectively at 3 uM; ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.
References	References 1. Fukumoto H, et al. J Neurosci. 2010 Aug 18;30(33):11157-66. 2. Takahashi H, et al. Brain Res. 2010 Nov 18;1361:146-56. View Related Products by Target Beta-secretase (BACE)