TAK-070
Modify Date: 2024-01-20 18:20:31
TAK-070 structure
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Common Name | TAK-070 | ||
|---|---|---|---|---|
| CAS Number | 365276-12-6 | Molecular Weight | 440.017 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C27H31NO.HCl.H2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TAK-070A selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays; suppresses the secretion of Aβ with minimum effective concentrations (MECs) for Aβ40 and Aβ42 of 100 and 1000 nM respectively in human IMR-32 neuroblastoma cells, also stimulates sAPPα production with MEC of 100 nM, significantly decreases the secreted level of both human Swedish sAPPβ and mouse endogenous sAPPβ, N-terminal counterparts of APP generated by BACE1 cleavage, by ∼16 and ∼19% respectively at 3 uM; ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. |
| Name | TAK-070 |
|---|---|
| Synonym | More Synonyms |
| Description | A selective, nonpeptidic, noncompetitive BACE1 inhibitor with IC50 of 3.15 uM in cell-free assays; suppresses the secretion of Aβ with minimum effective concentrations (MECs) for Aβ40 and Aβ42 of 100 and 1000 nM respectively in human IMR-32 neuroblastoma cells, also stimulates sAPPα production with MEC of 100 nM, significantly decreases the secreted level of both human Swedish sAPPβ and mouse endogenous sAPPβ, N-terminal counterparts of APP generated by BACE1 cleavage, by ∼16 and ∼19% respectively at 3 uM; ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. |
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| References | References 1. Fukumoto H, et al. J Neurosci. 2010 Aug 18;30(33):11157-66. 2. Takahashi H, et al. Brain Res. 2010 Nov 18;1361:146-56. View Related Products by Target Beta-secretase (BACE) |
| Molecular Formula | C27H31NO.HCl.H2O |
|---|---|
| Molecular Weight | 440.017 |
| Exact Mass | 439.227814 |
| 2-[(2R)-6-(4-Biphenylylmethoxy)-1,2,3,4-tetrahydro-2-naphthalenyl]-N,N-dimethylethanamine hydrochloride hydrate |
| EAC604ZY07 |
| 2-Naphthaleneethanamine, 6-([1,1'-biphenyl]-4-ylmethoxy)-1,2,3,4-tetrahydro-N,N-dimethyl-, (2R)-, hydrochloride, hydrate (1:1:1) |
| TAK-070 |