421572-88-5
421572-88-5 structure
- Name: GNF-Pf-5660
- Chemical Name: Ethyl 4-(2-chlorophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate
- CAS Number: 421572-88-5
- Molecular Formula: C27H28ClNO5
- Molecular Weight: 481.968
- Create Date: 2020-01-19 22:18:56
- Modify Date: 2025-09-25 18:02:53
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An antimalarial candidate that demonstrates potent blood-stage and transmission-blocking activity, shows potent ABS activity (IC50 <25 nM) against drug-sensitive 3D7 and multidrug-resistant Dd2 parasites; the digestive vacuole membrane-spanning transporter PfMDR1 is a determinant of parasite resistance to GNF-Pf-5660.
| Name | Ethyl 4-(2-chlorophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate |
|---|---|
| Synonyms |
3-Quinolinecarboxylic acid, 4-(2-chlorophenyl)-7-(3,4-dimethoxyphenyl)-1,4,5,6,7,8-hexahydro-2-methyl-5-oxo-, ethyl ester
Ethyl 4-(2-chlorophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate |
| Description | An antimalarial candidate that demonstrates potent blood-stage and transmission-blocking activity, shows potent ABS activity (IC50 <25 nM) against drug-sensitive 3D7 and multidrug-resistant Dd2 parasites; the digestive vacuole membrane-spanning transporter PfMDR1 is a determinant of parasite resistance to GNF-Pf-5660. |
|---|---|
| References | References 1. Vanaerschot M, et al. Nat Microbiol. 2017 Oct;2(10):1403-1414. View Related Products by Target Parasite |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 604.9±55.0 °C at 760 mmHg |
| Molecular Formula | C27H28ClNO5 |
| Molecular Weight | 481.968 |
| Flash Point | 319.6±31.5 °C |
| Exact Mass | 481.165588 |
| LogP | 4.17 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.611 |