505056-50-8

505056-50-8 structure

Name: CP-9
Chemical Name: N-(5-Methyl-1,2-oxazol-3-yl)-2-{[4-(2-thienyl)-6-(trifluoromethyl)-2-pyrimidinyl]sulfanyl}acetamide
CAS Number: 505056-50-8
Molecular Formula: C₁₅H₁₁F₃N₄O₂S₂
Molecular Weight: 400.399
Create Date: 2020-01-11 12:00:58
Modify Date: 2024-01-09 10:31:52
A potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM; 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM); leads to various levels of degradation of pAkt/total Akt and Raf-1 in cancer cell lines, but has no effect on the expression of the Hsp90 client proteins in normal mouse embryonic fibroblasts (MEFs); inhibits cell proliferation, glucose metabolism, and mammalian thymidine kinase activities in multiple cancer cell lines.

Name	N-(5-Methyl-1,2-oxazol-3-yl)-2-{[4-(2-thienyl)-6-(trifluoromethyl)-2-pyrimidinyl]sulfanyl}acetamide
Synonyms	N-(5-Methyl-1,2-oxazol-3-yl)-2-{[4-(2-thienyl)-6-(trifluoromethyl)-2-pyrimidinyl]sulfanyl}acetamide N-(5-Methyl-1,2-oxazol-3-yl)-2-{[4-(2-thienyl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl}acetamide Acetamide, N-(5-methyl-3-isoxazolyl)-2-[[4-(2-thienyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]-

Description	A potent Hsp90α/p23 interaction inhibitor with IC50 of 3.2 uM; 5-fold less potent for Hsp90β/p23 interaction (IC50=15.3 uM); leads to various levels of degradation of pAkt/total Akt and Raf-1 in cancer cell lines, but has no effect on the expression of the Hsp90 client proteins in normal mouse embryonic fibroblasts (MEFs); inhibits cell proliferation, glucose metabolism, and mammalian thymidine kinase activities in multiple cancer cell lines.
References	References 1. Chan CT, et al. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):E2476-85. View Related Products by Target Heat Shock Protein (HSP)