588678-13-1

588678-13-1 structure

Name: HlyU inhibitor CM14
Chemical Name: N-(4-Oxo-4H-thieno[3,4-c]chromen-3-yl)-3-phenyl-2-propynamide
CAS Number: 588678-13-1
Molecular Formula: C₂₀H₁₁NO₃S
Molecular Weight: 345.371
Create Date: 2020-01-11 17:18:34
Modify Date: 2023-01-17 06:30:08
HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30; reduces HlyU-dependent expression of virulence genes in V. vulnificus. In addition to the decreased hemolysis of human erythrocytes without affecting bacterial growth or triggering the host cell death; also reduces HlyU-dependent expression of virulence genes in V. vulnificus, decreases the expression of various virulence genes of other Vibrio species and thus attenuates their virulence phenotypes.

Name	N-(4-Oxo-4H-thieno[3,4-c]chromen-3-yl)-3-phenyl-2-propynamide
Synonyms	MFCD03943922 2-Propynamide, N-(4-oxo-4H-thieno[3,4-c][1]benzopyran-3-yl)-3-phenyl- N-(4-Oxo-4H-thieno[3,4-c]chromen-3-yl)-3-phenyl-2-propynamide

Description	HlyU inhibitor CM14 (1025E12) is a specifc, small-molecule inhibitor of transcriptional regulator HlyU activity with EC50 of 30.97 uM, inhibits HlyU from binding to target DNA by covalently modifying Cys30; reduces HlyU-dependent expression of virulence genes in V. vulnificus. In addition to the decreased hemolysis of human erythrocytes without affecting bacterial growth or triggering the host cell death; also reduces HlyU-dependent expression of virulence genes in V. vulnificus, decreases the expression of various virulence genes of other Vibrio species and thus attenuates their virulence phenotypes.
References	References 1. Lee ZW, et al. Sci Rep. 2019 Mar 13;9(1):4346. doi: 10.1038/s41598-019-39554-y. View Related Products by Target Other Targets