620589-62-0
620589-62-0 structure
- Name: TRIF agonist AV-C
- Chemical Name: 1-(2-Fluorophenyl)-2-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione
- CAS Number: 620589-62-0
- Molecular Formula: C22H16FN3O3S
- Molecular Weight: 421.444
- Create Date: 2020-01-20 17:47:56
- Modify Date: 2024-05-12 02:07:15
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TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM); activates IFNAR-mediated transcription and translation of antiviral effector genes, AV-C-mediated, IRF3-dependent innate activation occurs independently of adaptor proteins IPS-1/MAVS and STING but requires TRIF.
| Name | 1-(2-Fluorophenyl)-2-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione |
|---|---|
| Synonyms |
[1]Benzopyrano[2,3-c]pyrrole-3,9-dione, 1-(2-fluorophenyl)-1,2-dihydro-2-[5-(1-methylethyl)-1,3,4-thiadiazol-2-yl]-
MFCD04448398 1-(2-Fluorophenyl)-2-(5-isopropyl-1,3,4-thiadiazol-2-yl)-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-dione |
| Description | TRIF agonist AV-C is a novel TRIF pathway agonist that activates innate and interferon-associated responses, strongly inhibits replication of ZIKV, CHIKV, and DENV (IC90~5 uM); activates IFNAR-mediated transcription and translation of antiviral effector genes, AV-C-mediated, IRF3-dependent innate activation occurs independently of adaptor proteins IPS-1/MAVS and STING but requires TRIF. |
|---|---|
| References | References 1. Pryke KM, et al. MBio. 2017 May 2;8(3). pii: e00452-17. View Related Products by Target Other Targets |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 560.6±60.0 °C at 760 mmHg |
| Molecular Formula | C22H16FN3O3S |
| Molecular Weight | 421.444 |
| Flash Point | 292.8±32.9 °C |
| Exact Mass | 421.089630 |
| LogP | 3.72 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.692 |