870603-16-0
870603-16-0 structure
- Name: XL-281
- Chemical Name: BMS-908662
- CAS Number: 870603-16-0
- Molecular Formula: C24H19ClN4O4
- Molecular Weight: 462.885
- Create Date: 2020-01-11 17:00:50
- Modify Date: 2025-08-24 23:52:24
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XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models; demonstrates biological activity by modulation of the RAF pathway in tumor and surrogate tissue, with decreases in cell proliferation and increases in apoptosis. Colon Cancer Phase 2 Discontinued
| Name | BMS-908662 |
|---|---|
| Synonyms |
UNII:DW2NWI3TFN
Methyl {5-[2-(5-chloro-2-methylphenyl)-1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl]-1H-benzimidazol-2-yl}carbamate BMS-908662 Carbamic acid, N-[5-[2-(5-chloro-2-methylphenyl)-2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl]-1H-benzimidazol-2-yl]-, methyl ester DW2NWI3TFN |
| Description | XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models; demonstrates biological activity by modulation of the RAF pathway in tumor and surrogate tissue, with decreases in cell proliferation and increases in apoptosis. Colon Cancer Phase 2 Discontinued |
|---|---|
| References | References 1. Callahan MK, et al. Cancer Immunol Res. 2014 Jan;2(1):70-9. 2. Belum VR, et al. Cancer. 2015 Jan 1;121(1):60-8. 3. Dickson MA, et al. Invest New Drugs. 2015 Apr;33(2):349-56. View Related Products by Target Raf Colon Cancer |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H19ClN4O4 |
| Molecular Weight | 462.885 |
| Exact Mass | 462.109497 |
| LogP | 5.03 |
| Index of Refraction | 1.754 |