1071001-09-6

1071001-09-6 structure

Name: FKGK18
Chemical Name: 1,1,1-Trifluoro-6-(2-naphthyl)-2-hexanone
CAS Number: 1071001-09-6
Molecular Formula: C₁₆H₁₅F₃O
Molecular Weight: 280.285
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2020-01-11 19:19:50
Modify Date: 2024-04-05 19:45:03
FKGK18 (FKGK18) is a potent, selective inhibitor of iPLA2 (group VIA Ca2+-independent phospholipase A2) with IC50 of 50 nM; displays 195 and >455 times more potent for GVIA iPLA(2) than for GIVA cPLA(2) and GV sPLA(2); inhibits Ca2+-independent PLA2 activity in a concentration-dependent manner, similar to S-BEL, which preferentially inhibits cytosol-associated iPLA2β; FKGK18 a valuable tool to explore the role of GVIA iPLA(2) in cells and in vivo models.

Name	1,1,1-Trifluoro-6-(2-naphthyl)-2-hexanone
Synonyms	2-Hexanone, 1,1,1-trifluoro-6-(2-naphthalenyl)- 1,1,1-Trifluoro-6-(2-naphthyl)-2-hexanone

Description	FKGK18 (FKGK18) is a potent, selective inhibitor of iPLA2 (group VIA Ca2+-independent phospholipase A2) with IC50 of 50 nM; displays 195 and >455 times more potent for GVIA iPLA(2) than for GIVA cPLA(2) and GV sPLA(2); inhibits Ca2+-independent PLA2 activity in a concentration-dependent manner, similar to S-BEL, which preferentially inhibits cytosol-associated iPLA2β; FKGK18 a valuable tool to explore the role of GVIA iPLA(2) in cells and in vivo models.
References	References 1. Kokotos G, et al. J Med Chem. 2010 May 13;53(9):3602-10. 2. Ali T, et al. PLoS One. 2013 Aug 20;8(8):e71748. 3. Bone RN, et al. Diabetes. 2015 Feb;64(2):541-54. 4. Dedaki C, et al. J Med Chem. 2019 Mar 12. doi: 10.1021/acs.jmedchem.8b01216. View Related Products by Target Phospholipase