1189037-60-2
1189037-60-2 structure
- Name: Rivipansel sodium
- Chemical Name: Rivipansel sodium
- CAS Number: 1189037-60-2
- Molecular Formula: C58H74N6O31S3
- Molecular Weight: 1535.352
- Create Date: 2020-01-11 16:28:50
- Modify Date: 2025-08-25 17:32:20
-
Rivipansel sodium (GMI-1070, PF-06460031) is a novel small molecule glycomimetic pan-Selectin antagonist with IC50 of 4.3 uM, 423 uM and 337 uM for E-selectin, P-selectin and L-selectin, respectively; predominantly inhibits E-selectin-mediated adhesion and dramatically inhibits sRBC-leukocyte interactions, leading to improved microcirculatory blood flow and improved survival; a valuable novel therapeutic intervention for acute sickle cell crises. Anemia Phase 3 Clinical
| Name | Rivipansel sodium |
|---|---|
| Synonyms |
GMI-1070
PF-06460031-02 Rivipansel sodium β-D-Galactopyranoside, (1R,2R,3S,5R)-2-[(6-deoxy-α-L-galactopyranosyl)oxy]-3-[[(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinyl)carbonyl]amino]-5-[1,6,13-trioxo-13-[(3,6,8-trisulfo-1-naphthalenyl)am ino]-8,11-dioxa-2,5-diazatridec-1-yl]cyclohexyl 3-O-[(1S)-1-carboxy-2-cyclohexylethyl]-, 2-benzoate, sodium salt (1:4) Tetrasodium (1R,2R,3S,5R)-2-[(6-deoxy-α-L-galactopyranosyl)oxy]-3-{[(2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl)carbonyl]amino}-5-[(2-{[(2-{2-oxo-2-[(3,6,8-trisulfonato-1-naphthyl)amino]ethoxy}eth oxy)acetyl]amino}ethyl)carbamoyl]cyclohexyl 2-O-benzoyl-3-O-[(1S)-1-carboxylato-2-cyclohexylethyl]-β-D-galactopyranoside |
| Description | Rivipansel sodium (GMI-1070, PF-06460031) is a novel small molecule glycomimetic pan-Selectin antagonist with IC50 of 4.3 uM, 423 uM and 337 uM for E-selectin, P-selectin and L-selectin, respectively; predominantly inhibits E-selectin-mediated adhesion and dramatically inhibits sRBC-leukocyte interactions, leading to improved microcirculatory blood flow and improved survival; a valuable novel therapeutic intervention for acute sickle cell crises. Anemia Phase 3 Clinical |
|---|---|
| References | References 1. Chang J, et al. Blood. 2010 Sep 9;116(10):1779-86. 2. Azab AK, et al. Blood. 2012 Feb 9;119(6):1468-78. 3. Wun T, et al. PLoS One. 2014 Jul 2;9(7):e101301. View Related Products by Target Selectin Anemia |
| Molecular Formula | C58H74N6O31S3 |
|---|---|
| Molecular Weight | 1535.352 |
| Exact Mass | 1534.283813 |