1222173-37-6
1222173-37-6 structure
- Name: BI-4394
- Chemical Name: compound 15 [PMID: 22017539]
- CAS Number: 1222173-37-6
- Molecular Formula: C24H22N4O5
- Molecular Weight: 446.455
- Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
- Create Date: 2020-01-20 12:48:56
- Modify Date: 2024-09-17 10:18:17
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BI-4394 is a highly potent, selective MMP-13 inhibitor with IC50 of 1 nM, displays >1,000 fold selectivity against nine other MMP isoforms (MMP2/14, IC50=18/8.3 uM); BI-4394 is potent in a full-length MMP-13 collagen degradation assay (IC50=11 nM) and is able to inhibit degradation of bovine nasal cartilage with an IC50 of 31 nM.
| Name | compound 15 [PMID: 22017539] |
|---|---|
| Synonyms |
1H-Indole-2-carboxylic acid, 5-[3-[[[(4-carboxyphenyl)methyl]amino]carbonyl]-1-methyl-1H-pyrazol-5-yl]-, 2-ethyl ester
4-{[({5-[2-(Ethoxycarbonyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}carbonyl)amino]methyl}benzoic acid compound 15 [PMID: 22017539] |
| Description | BI-4394 is a highly potent, selective MMP-13 inhibitor with IC50 of 1 nM, displays >1,000 fold selectivity against nine other MMP isoforms (MMP2/14, IC50=18/8.3 uM); BI-4394 is potent in a full-length MMP-13 collagen degradation assay (IC50=11 nM) and is able to inhibit degradation of bovine nasal cartilage with an IC50 of 31 nM. |
|---|---|
| References | References 1. Taylor SJ, et al. J Med Chem. 2011 Dec 8;54(23):8174-87. View Related Products by Target Matrix Metalloproteinase (MMP) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 764.4±60.0 °C at 760 mmHg |
| Molecular Formula | C24H22N4O5 |
| Molecular Weight | 446.455 |
| Flash Point | 416.1±32.9 °C |
| Exact Mass | 446.159027 |
| LogP | 3.16 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.668 |