1394122-20-3

1394122-20-3 structure

Name: ADAMTS-5 inhibitor 8
Chemical Name: N-({(2R)-1-[4-(3-Buten-1-ylamino)-6-({[2-(2-thienyl)-1,3-thiazol-4-yl]methyl}amino)-1,3,5-triazin-2-yl]-2-pyrrolidinyl}methyl)-4-propylbenzenesulfonamide
CAS Number: 1394122-20-3
Molecular Formula: C₂₉H₃₆N₈O₂S₃
Molecular Weight: 624.844
Create Date: 2020-01-20 12:34:55
Modify Date: 2023-01-14 15:31:24
ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation.

Name	N-({(2R)-1-[4-(3-Buten-1-ylamino)-6-({[2-(2-thienyl)-1,3-thiazol-4-yl]methyl}amino)-1,3,5-triazin-2-yl]-2-pyrrolidinyl}methyl)-4-propylbenzenesulfonamide
Synonyms	N-({(2R)-1-[4-(3-Buten-1-ylamino)-6-({[2-(2-thienyl)-1,3-thiazol-4-yl]methyl}amino)-1,3,5-triazin-2-yl]-2-pyrrolidinyl}methyl)-4-propylbenzenesulfonamide Benzenesulfonamide, N-[[(2R)-1-[4-(3-buten-1-ylamino)-6-[[[2-(2-thienyl)-4-thiazolyl]methyl]amino]-1,3,5-triazin-2-yl]-2-pyrrolidinyl]methyl]-4-propyl-

Description	ADAMTS-5 inhibitor 8 is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation.
References	References 1. Deng H, et al. J Med Chem. 2012 Aug 23;55(16):7061-79. View Related Products by Target Matrix Metalloproteinase (MMP)