1394122-49-6

1394122-49-6 structure

Name: ADAMTS-5 inhibitor 15f
Chemical Name: ADAMTS-5 inhibitor 15f
CAS Number: 1394122-49-6
Molecular Formula: C₂₆H₃₉N₉O₂S
Molecular Weight: 541.719
Create Date: 2020-01-19 20:28:56
Modify Date: 2024-01-23 15:43:07
ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation.

Name	ADAMTS-5 inhibitor 15f

Description	ADAMTS-5 inhibitor 15f is a highly potent and selective inhibitor of metalloprotease ADAMTS-5 with IC50 of 30 nM, >50-fold selectivity against ADAMTS-4 and >1000-fold selectivity against ADAMTS-1/13, MMP-13 and TACE; inhibits aggrecanase-mediated (374)ARGS neoepitope release from aggrecan and glycosaminoglycan in response to IL-1β/OSM stimulation.
References	References 1. Deng H, et al. J Med Chem. 2012 Aug 23;55(16):7061-79. View Related Products by Target Matrix Metalloproteinase (MMP)

Molecular Formula	C₂₆H₃₉N₉O₂S
Molecular Weight	541.719