328104-79-6
328104-79-6 structure
- Name: DNMDP
- Chemical Name: 6-[4-(Diethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone
- CAS Number: 328104-79-6
- Molecular Formula: C15H20N4O3
- Molecular Weight: 304.344
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
- Create Date: 2020-01-12 03:35:30
- Modify Date: 2024-01-05 10:34:12
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DNMDP is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12); coexpression of SLFN12 with PDE3A correlates with DNMDP sensitivity, whereas depletion of SLFN12 results in decreased DNMDP sensitivity.
| Name | 6-[4-(Diethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone |
|---|---|
| Synonyms |
6-[4-(Diethylamino)-3-nitrophenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone
3(2H)-Pyridazinone, 6-[4-(diethylamino)-3-nitrophenyl]-4,5-dihydro-5-methyl- MFCD01829240 |
| Description | DNMDP is a potent and selective cancer cell cytotoxic agent that binds to PDE3A, promotes an interaction between PDE3A and Schlafen 12 (SLFN12); coexpression of SLFN12 with PDE3A correlates with DNMDP sensitivity, whereas depletion of SLFN12 results in decreased DNMDP sensitivity. |
|---|---|
| References | References 1. de Waal L, et al. Nat Chem Biol. 2016 Feb;12(2):102-8. 2. Vandenberghe P, et al. Oncotarget. 2017 Jun 20;8(25):41026-41043. View Related Products by Target Phosphodiesterase (PDE) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C15H20N4O3 |
| Molecular Weight | 304.344 |
| Exact Mass | 304.153534 |
| LogP | 1.49 |
| Index of Refraction | 1.613 |
| Storage condition | -20°C |