852146-75-9

852146-75-9 structure

Name: KR-32570
Chemical Name: KR-32570
CAS Number: 852146-75-9
Molecular Formula: C₁₃H₁₂ClN₃O₃
Molecular Weight: 293.706
Create Date: 2020-01-11 15:44:52
Modify Date: 2024-01-04 20:48:12
KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM; significantly and concentration dependently improves cardiac contractile function and severe contracture in conjunction with causing a marked reduction in lactate dehydrogenase release at 1-10 uM, possesses potent cardioprotective effects in perfused rat hearts.

Name	KR-32570
Synonyms	2-Furancarboxamide, 5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylene)- 5-(5-Chloro-2-methoxyphenyl)-N-(diaminomethylene)-2-furamide 5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylidene)furan-2-carboxamide KR-32570

Description	KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM; significantly and concentration dependently improves cardiac contractile function and severe contracture in conjunction with causing a marked reduction in lactate dehydrogenase release at 1-10 uM, possesses potent cardioprotective effects in perfused rat hearts.
References	References 1. Lee BH, et al. Eur J Pharmacol. 2005 Mar 28;511(2-3):175-82. 2. Lee S, et al. J Med Chem. 2005 Apr 21;48(8):2882-91. 3. Kim MJ, et al. Eur J Pharmacol. 2005 Nov 21;525(1-3):1-7. 4. Lee KS, et al. Arch Pharm Res. 2006 May;29(5):375-83. View Related Products by Target Sodium Channel