852146-75-9
852146-75-9 structure
- Name: KR-32570
- Chemical Name: KR-32570
- CAS Number: 852146-75-9
- Molecular Formula: C13H12ClN3O3
- Molecular Weight: 293.706
- Create Date: 2020-01-11 15:44:52
- Modify Date: 2024-01-04 20:48:12
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KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM; significantly and concentration dependently improves cardiac contractile function and severe contracture in conjunction with causing a marked reduction in lactate dehydrogenase release at 1-10 uM, possesses potent cardioprotective effects in perfused rat hearts.
| Name | KR-32570 |
|---|---|
| Synonyms |
2-Furancarboxamide, 5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylene)-
5-(5-Chloro-2-methoxyphenyl)-N-(diaminomethylene)-2-furamide 5-(5-chloro-2-methoxyphenyl)-N-(diaminomethylidene)furan-2-carboxamide KR-32570 |
| Description | KR-32570 is a potent sodium hydrogen exchanger NHE1 inhibitor with IC50 of 50 nM; significantly and concentration dependently improves cardiac contractile function and severe contracture in conjunction with causing a marked reduction in lactate dehydrogenase release at 1-10 uM, possesses potent cardioprotective effects in perfused rat hearts. |
|---|---|
| References | References 1. Lee BH, et al. Eur J Pharmacol. 2005 Mar 28;511(2-3):175-82. 2. Lee S, et al. J Med Chem. 2005 Apr 21;48(8):2882-91. 3. Kim MJ, et al. Eur J Pharmacol. 2005 Nov 21;525(1-3):1-7. 4. Lee KS, et al. Arch Pharm Res. 2006 May;29(5):375-83. View Related Products by Target Sodium Channel |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 474.4±55.0 °C at 760 mmHg |
| Molecular Formula | C13H12ClN3O3 |
| Molecular Weight | 293.706 |
| Flash Point | 240.7±31.5 °C |
| Exact Mass | 293.056732 |
| LogP | 1.28 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.635 |