761414-79-3

761414-79-3 structure

Name: KR-62436
Chemical Name: KR-60436 FREE BASE
CAS Number: 761414-79-3
Molecular Formula: C₁₄H₁₅N₇O
Molecular Weight: 297.315
Create Date: 2020-01-11 23:34:56
Modify Date: 2024-01-01 19:16:01
KR-62436 (KR62436) is a potent, selective DPP4 inhibitor with IC50 of 0.78, 0.49, 0.14 uM for rat plasma, porcine kidney, human DPP4 (Caco-2), respectively; completely inhibits DPP-IV-mediated degradation of GLP-1 in vitro at 10 uM, exhibits selectivity against several proteases including proline-specific protease; promotes primary tumor growth and lung metastasis in a 4T1 tumor allograft mouse model, also shows anti-hyperglycemic activity in vivo.

Name	KR-60436 FREE BASE
Synonyms	3-Pyridinecarbonitrile, 6-[[2-[[2-(5-cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]amino]ethyl]amino]- 6-[(2-{[2-(5-cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]amino}ethyl)amino]pyridine-3-carbonitrile KR-60436 FREE BASE 6-[(2-{[2-(5-Cyano-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethyl]amino}ethyl)amino]nicotinonitrile

Description	KR-62436 (KR62436) is a potent, selective DPP4 inhibitor with IC50 of 0.78, 0.49, 0.14 uM for rat plasma, porcine kidney, human DPP4 (Caco-2), respectively; completely inhibits DPP-IV-mediated degradation of GLP-1 in vitro at 10 uM, exhibits selectivity against several proteases including proline-specific protease; promotes primary tumor growth and lung metastasis in a 4T1 tumor allograft mouse model, also shows anti-hyperglycemic activity in vivo.
References	References 1. Kim KR, et al. Eur J Pharmacol. 2005 Jul 25;518(1):63-70. 2. Yang F, et al. Cancer Res. 2018 Dec 24. pii: canres.0620.2018. doi: 10.1158/0008-5472.CAN-18-0620. View Related Products by Target Dipeptidyl Peptidase (DPP)