895169-20-7
895169-20-7 structure
- Name: ONO-2952
- Chemical Name: 1-[(1S)-1-(4-Chloro-2-methoxyphenyl)-5-fluoro-1,9-dihydrospiro[β-carboline-4,1'-cyclopropan]-2(3H)-yl]ethanone
- CAS Number: 895169-20-7
- Molecular Formula: C22H20ClFN2O2
- Molecular Weight: 398.858
- Catalog: Research Areas Neurological Disease
- Create Date: 2020-01-12 07:26:50
- Modify Date: 2024-01-06 15:55:37
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A novel potent, selective, orally active translocator protein 18 kDa (TSPO/PBR) antagonist with Ki of 0.33-9.3 nM for both rat and human TSPO; displays high selectivity over 98 other receptors, transporters, ion channels and enzymes; inhibits both neurosteroid accumulation and noradrenaline release in the brain of rats exposed to acute stress; suppresses conditioned fear stress-induced freezing behavior in rats with an efficacy equivalent to that of diazepam, but without not affect learning and memory. Irritable Bowel Syndrome Phase 2 Clinical
| Name | 1-[(1S)-1-(4-Chloro-2-methoxyphenyl)-5-fluoro-1,9-dihydrospiro[β-carboline-4,1'-cyclopropan]-2(3H)-yl]ethanone |
|---|---|
| Synonyms |
Ethanone, 1-[(1'S)-1'-(4-chloro-2-methoxyphenyl)-5'-fluoro-1',9'-dihydrospiro[cyclopropane-1,4'-[4H]pyrido[3,4-b]indol]-2'(3'H)-yl]-
1-[(1S)-1-(4-Chloro-2-methoxyphenyl)-5-fluoro-1,9-dihydrospiro[β-carboline-4,1'-cyclopropan]-2(3H)-yl]ethanone |
| Description | A novel potent, selective, orally active translocator protein 18 kDa (TSPO/PBR) antagonist with Ki of 0.33-9.3 nM for both rat and human TSPO; displays high selectivity over 98 other receptors, transporters, ion channels and enzymes; inhibits both neurosteroid accumulation and noradrenaline release in the brain of rats exposed to acute stress; suppresses conditioned fear stress-induced freezing behavior in rats with an efficacy equivalent to that of diazepam, but without not affect learning and memory. Irritable Bowel Syndrome Phase 2 Clinical |
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| Related Catalog | |
| Target |
Ki: 0.33-9.30 nM (Rat and human TSPO)[1] |
| In Vitro | As for its selectivity for TSPO, ONO-2952 at a concentration of 10 μM showed good selectivity for TSPO against 98 off-targets (<50% inhibition). Determination of ONO-2952 Ki or IC50 values for the remaining 35 targets (50% inhibition at 10 μM) reveal Ki values of less than 1 μM only for 3 receptors, i.e. melatonin 2, progesterone B, and adrenergic α2C. The affinity of ONO-2952 for these receptors is at least 59 times lower than that for TSPO. ONO-2952 Ki value for the GABAA receptor is more than 600 times higher than that for TSPO[1]. |
| In Vivo | ONO-2952 (0.03-3 mg/kg; oral administration; male Sprague Dawley rats) treatment dose-dependently suppresses restraint stress-induced defecation in rats with brain TSPO occupancy of more than 50%. ONO-2952 also suppresses conditioned fear stress-induced freezing behavior in rats[1]. ONO-2952 inhibits both neurosteroid accumulation and noradrenaline release in the brain of rats exposed to acute stress[1]. Animal Model: Male Sprague Dawley rats (8 weeks old) under conditioned fear stress test[1] Dosage: 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg Administration: Oral administration Result: Dose-dependently suppressed restraint stress-induced defecation in rats. And suppressed conditioned fear stress-induced freezing behavior in rats. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 609.4±55.0 °C at 760 mmHg |
| Molecular Formula | C22H20ClFN2O2 |
| Molecular Weight | 398.858 |
| Flash Point | 322.3±31.5 °C |
| Exact Mass | 398.119720 |
| LogP | 4.15 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.682 |