927872-24-0
927872-24-0 structure
- Name: AF-792
- Chemical Name: 5-(5-Ethynyl-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine
- CAS Number: 927872-24-0
- Molecular Formula: C16H18N4O2
- Molecular Weight: 298.340
- Create Date: 2020-01-11 18:21:39
- Modify Date: 2023-01-15 20:59:59
-
AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors; significantly inhibits micturition reflex activity, attenuates spinal activation of extracellular-signal regulated kinases (ERK) induced by acute peripheral stimulation of the bladder in vivo.
| Name | 5-(5-Ethynyl-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine |
|---|---|
| Synonyms |
2,4-Pyrimidinediamine, 5-[5-ethynyl-4-methoxy-2-(1-methylethyl)phenoxy]-
5-(5-Ethynyl-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine |
| Description | AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors; significantly inhibits micturition reflex activity, attenuates spinal activation of extracellular-signal regulated kinases (ERK) induced by acute peripheral stimulation of the bladder in vivo. |
|---|---|
| References | References 1. Carter DS, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1628-31. 2. Kaan TK, et al. J Neurosci. 2010 Mar 24;30(12):4503-7. View Related Products by Target P2X Receptor |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 490.8±55.0 °C at 760 mmHg |
| Molecular Formula | C16H18N4O2 |
| Molecular Weight | 298.340 |
| Flash Point | 250.7±31.5 °C |
| Exact Mass | 298.142975 |
| LogP | 2.36 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.620 |