AF-792
Modify Date: 2023-01-15 20:59:59
AF-792 structure
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Common Name | AF-792 | ||
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| CAS Number | 927872-24-0 | Molecular Weight | 298.340 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 490.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C16H18N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 250.7±31.5 °C | |
Use of AF-792AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors; significantly inhibits micturition reflex activity, attenuates spinal activation of extracellular-signal regulated kinases (ERK) induced by acute peripheral stimulation of the bladder in vivo. |
| Name | 5-(5-Ethynyl-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine |
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| Synonym | More Synonyms |
| Description | AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors; significantly inhibits micturition reflex activity, attenuates spinal activation of extracellular-signal regulated kinases (ERK) induced by acute peripheral stimulation of the bladder in vivo. |
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| References | References 1. Carter DS, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1628-31. 2. Kaan TK, et al. J Neurosci. 2010 Mar 24;30(12):4503-7. View Related Products by Target P2X Receptor |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 490.8±55.0 °C at 760 mmHg |
| Molecular Formula | C16H18N4O2 |
| Molecular Weight | 298.340 |
| Flash Point | 250.7±31.5 °C |
| Exact Mass | 298.142975 |
| LogP | 2.36 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.620 |
| 2,4-Pyrimidinediamine, 5-[5-ethynyl-4-methoxy-2-(1-methylethyl)phenoxy]- |
| 5-(5-Ethynyl-2-isopropyl-4-methoxyphenoxy)-2,4-pyrimidinediamine |