1644029-01-5

1644029-01-5 structure

Name: RORγt inverse agonist 22
Chemical Name: RORγt inverse agonist 22
CAS Number: 1644029-01-5
Molecular Formula: C₂₃H₂₅F₂N₃O₅Si
Molecular Weight: 489.551
Create Date: 2020-01-11 18:44:50
Modify Date: 2024-04-05 19:32:29
RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ; exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors; demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration.

Name	RORγt inverse agonist 22

Description	RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ; exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors; demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration.
References	References 1. Shirai J, et al. Bioorg Med Chem. 2018 Jan 15;26(2):483-500. View Related Products by Target ROR

Molecular Formula	C₂₃H₂₅F₂N₃O₅Si
Molecular Weight	489.551