1644029-01-5
1644029-01-5 structure
- Name: RORγt inverse agonist 22
- Chemical Name: RORγt inverse agonist 22
- CAS Number: 1644029-01-5
- Molecular Formula: C23H25F2N3O5Si
- Molecular Weight: 489.551
- Create Date: 2020-01-11 18:44:50
- Modify Date: 2024-04-05 19:32:29
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RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ; exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors; demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration.
| Name | RORγt inverse agonist 22 |
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| Description | RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ; exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors; demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration. |
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| References | References 1. Shirai J, et al. Bioorg Med Chem. 2018 Jan 15;26(2):483-500. View Related Products by Target ROR |
| Molecular Formula | C23H25F2N3O5Si |
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| Molecular Weight | 489.551 |