1445901-41-6

1445901-41-6 structure

1445901-41-6 structure

Name: RORγt inverse agonist 30
Chemical Name: RORγt inverse agonist 30
CAS Number: 1445901-41-6
Molecular Formula: C₂₄H₃₁N₃O₃S
Molecular Weight: 441.59
Catalog: Signaling Pathways Metabolic Enzyme/Protease ROR
Create Date: 2022-08-10 17:54:03
Modify Date: 2024-01-12 17:11:57
RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders[1].

Name	RORγt inverse agonist 30

Description	RORγt inverse agonist 30 (Compound 1) is a potent RORγt inverse agonist with the IC50 of 46 nM. Targeting the nuclear receptor RORγt is effective in autoimmune disorders[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ROR Research Areas >> Inflammation/Immunology
Target	RORγt:46 nM (IC50)
In Vitro	RORγt inverse agonist 30 (compound 1) inhibits mouse Th17 cell differentiation with an IC50 of 0.67 μM[1].
In Vivo	RORγt inverse agonist 30 exhibits favorable pharmacokinetics profiles with T1/2 of 2.3 min, CLint of 612 μL/min/mg and CLint(liver) of 2423.5 mL/min/kg[1].
References	[1]. Nannan Sun, et al. Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases. Eur J Med Chem. 2020 Feb 1;187:111984.

Molecular Formula	C₂₄H₃₁N₃O₃S
Molecular Weight	441.59