1884472-26-7
1884472-26-7 structure
- Name: β-catenin-IN-11a
- Chemical Name: β-catenin-IN-11a
- CAS Number: 1884472-26-7
- Molecular Formula: C31H28N4O3
- Molecular Weight: 504.59
- Create Date: 2020-01-20 13:27:56
- Modify Date: 2023-01-17 11:20:25
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β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex; blocks the cell cycle inhibitory effect of CD44 and induces cell accumulation of CD44 high cells in cycling phase in S, G2 and M phase, leads to inhibition of embryonic transcriptional factor Nanog but not Sox2 or Oct-4 in colon cancer cells.
| Name | β-catenin-IN-11a |
|---|
| Description | β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex; blocks the cell cycle inhibitory effect of CD44 and induces cell accumulation of CD44 high cells in cycling phase in S, G2 and M phase, leads to inhibition of embryonic transcriptional factor Nanog but not Sox2 or Oct-4 in colon cancer cells. |
|---|---|
| References | References 1. Radwan AA, et al. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1664-70. View Related Products by Target Beta-catenin |
| Molecular Formula | C31H28N4O3 |
|---|---|
| Molecular Weight | 504.59 |