1227206-13-4
1227206-13-4 structure
- Name: BTK-IN-23
- Chemical Name: BTK-IN-23
- CAS Number: 1227206-13-4
- Molecular Formula: C27H24FN7O2S
- Molecular Weight: 529.594
- Create Date: 2020-01-12 18:58:45
- Modify Date: 2024-01-19 20:31:09
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BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM; displays 5-fold and 77-fold selectivity over BMX and TEC, >300-fold selectivity over FGR, SRC and MELK; demonstrates potent inhibition of anti-IgE stimulated CD63 expression on basophils, with an EC50 of 257 nM; shows improved stability compared to GDC-0834.
| Name | BTK-IN-23 |
|---|
| Description | BTK-IN-23 is a highly potent and selective Btk inhibitor with IC50 of 3 nM; displays 5-fold and 77-fold selectivity over BMX and TEC, >300-fold selectivity over FGR, SRC and MELK; demonstrates potent inhibition of anti-IgE stimulated CD63 expression on basophils, with an EC50 of 257 nM; shows improved stability compared to GDC-0834. |
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| References | References 1. Young WB, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):575-9. View Related Products by Target BTK |
| Molecular Formula | C27H24FN7O2S |
|---|---|
| Molecular Weight | 529.594 |