1314958-91-2
1314958-91-2 structure
- Name: BRD 0476
- Chemical Name: BRD 0476
- CAS Number: 1314958-91-2
- Molecular Formula: C35H38N4O8S
- Molecular Weight: 674.769
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2020-01-20 10:04:56
- Modify Date: 2024-04-11 10:13:07
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BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival; does not has kinase inhibitory activity, and no effect no effect on JAK1, JAK2, or JAK3 activities, and the deubiquitinase ubiquitin-specific peptidase 9X (USP9X) is an intracellular target of BRD0476.
| Name | BRD 0476 |
|---|
| Description | BRD 0476 (ML187) is a selective, moderate inhibitor of ubiquitin-specific peptidase 9X (USP9X), inhibits pancreatic β-cell apoptosis that inhibits IFN-γ-induced JAK2 and STAT1 signaling to promote β-cell survival; does not has kinase inhibitory activity, and no effect no effect on JAK1, JAK2, or JAK3 activities, and the deubiquitinase ubiquitin-specific peptidase 9X (USP9X) is an intracellular target of BRD0476. |
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| References | References 1. Chou DH, et al. J Am Chem Soc. 2015 Jun 24;137(24):7929-34. 2. Faloon PW, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 3. Chou DH, et al. ACS Med Chem Lett. 2011 Sep 8;2(9):698-702. View Related Products by Target Deubiquitinase (DUB) |
| Molecular Formula | C35H38N4O8S |
|---|---|
| Molecular Weight | 674.769 |