1355687-91-0
1355687-91-0 structure
- Name: DSR-71167
- Chemical Name: DSR-71167
- CAS Number: 1355687-91-0
- Molecular Formula: C23H23ClF3N3O4S
- Molecular Weight: 529.959
- Create Date: 2020-01-11 19:15:49
- Modify Date: 2024-07-18 19:14:03
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A novel mineralocorticoid receptor antagonist (IC50=0.26 uM) with carbonic anhydrase inhibitory activity (IC50=19 uM); displays >42-fold selectivity over other steroid receptors (AR, PR and GR); dose-dependently increases urinary excretion of sodium in deoxycorticosterone acetate-treated rats without elevating serum levels of potassium, but not the DSR-30192 (NO carbonic anhydrase inhibitory activity, IC50>100 uM); shows antihypertensive effects in rats.
| Name | DSR-71167 |
|---|
| Description | A novel mineralocorticoid receptor antagonist (IC50=0.26 uM) with carbonic anhydrase inhibitory activity (IC50=19 uM); displays >42-fold selectivity over other steroid receptors (AR, PR and GR); dose-dependently increases urinary excretion of sodium in deoxycorticosterone acetate-treated rats without elevating serum levels of potassium, but not the DSR-30192 (NO carbonic anhydrase inhibitory activity, IC50>100 uM); shows antihypertensive effects in rats. |
|---|---|
| References | References 1. Nariai T, et al. J Pharmacol Exp Ther. 2015 Jul;354(1):2-9. View Related Products by Target Mineralocorticoid Receptor (MLR) |
| Molecular Formula | C23H23ClF3N3O4S |
|---|---|
| Molecular Weight | 529.959 |