1538574-95-6
1538574-95-6 structure
- Name: S1P Lyase inhibitor 31
- Chemical Name: S1P Lyase inhibitor 31
- CAS Number: 1538574-95-6
- Molecular Formula: C26H23ClN6
- Molecular Weight: 454.962
- Create Date: 2020-01-20 11:47:57
- Modify Date: 2024-02-28 17:39:09
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A potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM; displays acceptable selectivity in a panel of 74 receptors and enzymes at 10 uM; induces profound reduction of peripheral T cell numbers after oral dosage and confers pronounced protection in a rat model of multiple sclerosis.
| Name | S1P Lyase inhibitor 31 |
|---|
| Description | A potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM; displays acceptable selectivity in a panel of 74 receptors and enzymes at 10 uM; induces profound reduction of peripheral T cell numbers after oral dosage and confers pronounced protection in a rat model of multiple sclerosis. |
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| References | References 1. Harris CM, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):151-8. 2. Weiler S, et al. J Med Chem. 2014 Jun 26;57(12):5074-84. View Related Products by Target Other Targets |
| Molecular Formula | C26H23ClN6 |
|---|---|
| Molecular Weight | 454.962 |