1637749-82-6
1637749-82-6 structure
- Name: JKA3 inhibitor 31
- Chemical Name: JKA3 inhibitor 31
- CAS Number: 1637749-82-6
- Molecular Formula: C17H12N4O
- Molecular Weight: 288.31
- Create Date: 2020-01-11 15:34:50
- Modify Date: 2024-01-18 21:57:37
-
JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases; also inhibits BLK, ERB-B4 and ITK with IC50 of 22 nM, 44 nM and 221 nM, respectively.
| Name | JKA3 inhibitor 31 |
|---|
| Description | JKA3 inhibitor 31 is a highly potent, selective, reversible, covalent JAK3 inhibitor with IC50 of 49 nM, shows no activity against other JAK kinases; also inhibits BLK, ERB-B4 and ITK with IC50 of 22 nM, 44 nM and 221 nM, respectively. |
|---|---|
| References | References 1. London N, et al. Nat Chem Biol. 2014 Dec;10(12):1066-72. 2. Clark JD, et al. J Med Chem. 2014 Jun 26;57(12):5023-38. View Related Products by Target JAK |
| Molecular Formula | C17H12N4O |
|---|---|
| Molecular Weight | 288.31 |