1627715-60-9
1627715-60-9 structure
- Name: RX-37
- Chemical Name: RX-37
- CAS Number: 1627715-60-9
- Molecular Formula: C24H23N5O2
- Molecular Weight: 413.481
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2020-01-19 20:56:55
- Modify Date: 2024-01-10 11:29:50
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A potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4; shows an excellent selectivity over other non-BET bromodomain-containing proteins with the exception of CREBBP (Kd=670 nM); potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged MLL1 gene (IC50=20 nM for MV4;11 cells).
| Name | RX-37 |
|---|
| Description | A potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4; shows an excellent selectivity over other non-BET bromodomain-containing proteins with the exception of CREBBP (Kd=670 nM); potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged MLL1 gene (IC50=20 nM for MV4;11 cells). |
|---|---|
| References | References 1. Ran X, et al. J Med Chem. 2015 Jun 25;58(12):4927-39. View Related Products by Target Bromodomain |
| Molecular Formula | C24H23N5O2 |
|---|---|
| Molecular Weight | 413.481 |