RX-37
Modify Date: 2024-01-10 11:29:50
RX-37 structure
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Common Name | RX-37 | ||
|---|---|---|---|---|
| CAS Number | 1627715-60-9 | Molecular Weight | 413.481 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H23N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RX-37A potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4; shows an excellent selectivity over other non-BET bromodomain-containing proteins with the exception of CREBBP (Kd=670 nM); potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged MLL1 gene (IC50=20 nM for MV4;11 cells). |
| Name | RX-37 |
|---|
| Description | A potent and specific BET bromodomain inhibitor with Ki of 3.2-24.7 nM for BD1 and BD2 domains of BRD2, BRD3, and BRD4; shows an excellent selectivity over other non-BET bromodomain-containing proteins with the exception of CREBBP (Kd=670 nM); potently and selectively inhibits cell growth in human acute leukemia cell lines harboring the rearranged MLL1 gene (IC50=20 nM for MV4;11 cells). |
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| References | References 1. Ran X, et al. J Med Chem. 2015 Jun 25;58(12):4927-39. View Related Products by Target Bromodomain |
| Molecular Formula | C24H23N5O2 |
|---|---|
| Molecular Weight | 413.481 |