1883817-83-1
1883817-83-1 structure
- Name: ST-162
- Chemical Name: ST-162
- CAS Number: 1883817-83-1
- Molecular Formula: C40H44F5IN10O6
- Molecular Weight: 982.752
- Create Date: 2020-01-11 20:24:50
- Modify Date: 2024-02-28 17:46:36
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ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively; produces regression of mutant KRAS or BRAF addicted xenograft models of colorectal cancer and melanoma and stasis of BRAF/PTEN mutant melanomas; increases efficacy in a syngeneic KRAS mutant colorectal cancer model combined with checkpoint blocker PD-L1.
| Name | ST-162 |
|---|
| Description | ST-162 is a potent, bifunctional MAPK/PI3K antagonist with IC50 of 191 nM and 398 nM for PI3Kα and MEK1, respectively; produces regression of mutant KRAS or BRAF addicted xenograft models of colorectal cancer and melanoma and stasis of BRAF/PTEN mutant melanomas; increases efficacy in a syngeneic KRAS mutant colorectal cancer model combined with checkpoint blocker PD-L1. |
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| References | References 1. Galbán S, et al. Mol Cancer Ther. 2017 Nov;16(11):2340-2350. 2. Van Dort ME, et al. J Med Chem. 2016 Mar 24;59(6):2512-22. 3. Van Dort ME, et al. ACS Med Chem Lett. 2017 Jul 24;8(8):808-813. View Related Products by Target PI3K |
| Molecular Formula | C40H44F5IN10O6 |
|---|---|
| Molecular Weight | 982.752 |