2070015-00-6
2070015-00-6 structure
- Name: GNE-7915 tosylate
- Chemical Name: GNE-7915 tosylate
- CAS Number: 2070015-00-6
- Molecular Formula: C26H29F4N5O6S
- Molecular Weight: 615.597
- Create Date: 2020-01-11 19:31:49
- Modify Date: 2024-04-09 11:45:00
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GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM; shows 1/187 kinases with 50% inhibition at 0.1 uM; possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species. Parkinson's Disease Preclinical
| Name | GNE-7915 tosylate |
|---|
| Description | GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM; shows 1/187 kinases with 50% inhibition at 0.1 uM; possesses an ideal balance of LRRK2 cellular potency, broad kinase selectivity, metabolic stability, and brain penetration across multiple species. Parkinson's Disease Preclinical |
|---|---|
| References | References 1. Estrada AA, et al. J Med Chem. 2012 Nov 26;55(22):9416-33. 2. Fuji RN, et al. Sci Transl Med. 2015 Feb 4;7(273):273ra15. 3. Kavanagh ME, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3690-6. View Related Products by Target LRRK2 Parkinson Disease |
| Molecular Formula | C26H29F4N5O6S |
|---|---|
| Molecular Weight | 615.597 |
| Storage condition | 2-8℃ |