1953134-16-1
1953134-16-1 structure
- Name: GNE-502
- Chemical Name: GNE-502
- CAS Number: 1953134-16-1
- Molecular Formula: C25H30FN3O3S
- Molecular Weight: 471.59
- Catalog: Research Areas Cancer
- Create Date: 2021-11-04 20:13:10
- Modify Date: 2024-01-02 19:04:07
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GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer[1].
| Name | GNE-502 |
|---|
| Description | GNE-502 is an orally active and potent degrader for estrogen receptor (ER). GNE-502 can be used for the research of breast cancer[1]. |
|---|---|
| Related Catalog | |
| Target |
ER[1] |
| In Vivo | GNE-502 (10 and 100 mg/kg; p.o.) possesses sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model[1]. ..GNE-502 shows dose dependent tumor growth inhibition at 10 mg/kg and 30 mg/kg, with tumor stasis at 100 mg/kg[1]. Animal Model: Mouse[1] Dosage: 10 and 100 mg/kg (Pharmacokinetic Analysis) Administration: P.o. Result: Possessed sufficient oral exposure to be tested in a WT MCF7 tumor xenograft model. |
| References |
| Molecular Formula | C25H30FN3O3S |
|---|---|
| Molecular Weight | 471.59 |