2093407-25-9
2093407-25-9 structure
- Name: KY-02327
- Chemical Name: KY-02327
- CAS Number: 2093407-25-9
- Molecular Formula: C20H27N3O4
- Molecular Weight: 373.453
- Catalog: Signaling Pathways Stem Cell/Wnt Wnt
- Create Date: 2020-01-11 20:07:51
- Modify Date: 2024-04-13 10:13:49
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KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog; KY-02327 is more stable by 2.3-fold and 1.3-fold than KY-02061 in rat liver microsomes and in human hepatocytes, respectively; shows enhanced effect on induction of ALP activity of osteoblast cells compared with KY-02061; activates the Wnt/β-catenin pathway, promotes osteoblast differentiation, and rescues BMD, bone volume, and trabecular bone structures in variectomized (OVX) mouse model.
| Name | KY-02327 |
|---|
| Description | KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog; KY-02327 is more stable by 2.3-fold and 1.3-fold than KY-02061 in rat liver microsomes and in human hepatocytes, respectively; shows enhanced effect on induction of ALP activity of osteoblast cells compared with KY-02061; activates the Wnt/β-catenin pathway, promotes osteoblast differentiation, and rescues BMD, bone volume, and trabecular bone structures in variectomized (OVX) mouse model. |
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| References | References 1. Kim HY, et al. EMBO Mol Med. 2016 Apr 1;8(4):375-87. View Related Products by Target Dishevelled |
| Molecular Formula | C20H27N3O4 |
|---|---|
| Molecular Weight | 373.453 |
| Storage condition | -20°C |