KY-02327

Modify Date: 2024-04-13 10:13:49

KY-02327 Structure
KY-02327 structure
Common Name KY-02327
CAS Number 2093407-25-9 Molecular Weight 373.453
Density N/A Boiling Point N/A
Molecular Formula C20H27N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of KY-02327


KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog; KY-02327 is more stable by 2.3-fold and 1.3-fold than KY-02061 in rat liver microsomes and in human hepatocytes, respectively; shows enhanced effect on induction of ALP activity of osteoblast cells compared with KY-02061; activates the Wnt/β-catenin pathway, promotes osteoblast differentiation, and rescues BMD, bone volume, and trabecular bone structures in variectomized (OVX) mouse model.

 Names

Name KY-02327

 KY-02327 Biological Activity

Description KY-02327 is an orally active, small molecule inhibitor of the Dishevelled (Dvl)-CXXC5 interaction with IC50 of 3.1 uM, a metabolically stabilized KY-02061 analog; KY-02327 is more stable by 2.3-fold and 1.3-fold than KY-02061 in rat liver microsomes and in human hepatocytes, respectively; shows enhanced effect on induction of ALP activity of osteoblast cells compared with KY-02061; activates the Wnt/β-catenin pathway, promotes osteoblast differentiation, and rescues BMD, bone volume, and trabecular bone structures in variectomized (OVX) mouse model.
References References 1. Kim HY, et al. EMBO Mol Med. 2016 Apr 1;8(4):375-87. View Related Products by Target Dishevelled

 Chemical & Physical Properties

Molecular Formula C20H27N3O4
Molecular Weight 373.453
Storage condition -20°C
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