2241813-33-0
2241813-33-0 structure
- Name: Dual DDR1 and DDR2 inhibitor 5n
- Chemical Name: Dual DDR1 and DDR2 inhibitor 5n
- CAS Number: 2241813-33-0
- Molecular Formula: C31H31F3N6O
- Molecular Weight: 560.625
- Create Date: 2020-01-19 23:03:56
- Modify Date: 2024-01-07 18:20:03
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Dual DDR1 and DDR2 inhibitor 5n is a highly potent, selective, dual Discoidin domain receptor DDR1 and DDR2 inhibitor with Kd of 7.9 and 8.0 nM, IC50 of 9.4 and 20.4 nM, repectively; displays significant selectivity against a panel of 403 wild-type kinases at 1 uM (Abl1 IC50=494 nM); dose-dependently inhibited lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) release in mouse primary peritoneal macrophages (MPMs), attenuates lung pathophysiologic changes in LPS-challenged mice, effectively decreases the levels of TNF-α and IL-6 both in BALF and serum.
| Name | Dual DDR1 and DDR2 inhibitor 5n |
|---|
| Description | Dual DDR1 and DDR2 inhibitor 5n is a highly potent, selective, dual Discoidin domain receptor DDR1 and DDR2 inhibitor with Kd of 7.9 and 8.0 nM, IC50 of 9.4 and 20.4 nM, repectively; displays significant selectivity against a panel of 403 wild-type kinases at 1 uM (Abl1 IC50=494 nM); dose-dependently inhibited lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) release in mouse primary peritoneal macrophages (MPMs), attenuates lung pathophysiologic changes in LPS-challenged mice, effectively decreases the levels of TNF-α and IL-6 both in BALF and serum. |
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| References | References 1. Wang Z, et al. J Med Chem. 2018 Aug 3. doi: 10.1021/acs.jmedchem.8b01045. View Related Products by Target Discoidin Domain Receptor (DDR) |
| Molecular Formula | C31H31F3N6O |
|---|---|
| Molecular Weight | 560.625 |